National Heart, Lung, and Blood Institute program in
Acute Lung Injury
Specialized Centers of Clinically Oriented Research (ALI SCCOR)

FACULTY AND HOSPITAL POSITIONS:  University of Washington School of Medicine, Seattle WA
1980-92:          Instructor, Asst Prof, Assoc Prof of Medicine, Division of Pulmonary and Critical Care Medicine
1992-present:  Professor of Medicine, Division of Pulmonary and Critical Care Medicine
1993-2000:      Director, Pulmonary Cell/Molecular Biology Research Training Program, Pulm/Critical Care Med
2000-present   Vice Chair, Department of Medicine; Chief of Medicine, VA Puget Sound Health Care System

SPECIAL RESPONSIBILITIES:  VA Merit Review Board, Respiration 1990-93, (Chair 1992-93); NIH Lung Biol/Pathol A Study Section 1991-96, (Chair 1994-96); Associate Editor, AJRCCM (1999-2003); Associate Editor, European Respiratory Journal (2000-03); Editorial Board, Am J Physiol: Lung Cell Molec Phys (2000-03); APS Respiration Section (Chair 1996-99); VA Medical Research Advisory Group (1999-03, Chair 2002-03); VA Blue Ribbon Lab Science Committee (2003); NHLBI Program Project Parent Committee (1999-2002); American Thoracic Society (ATS) President 2002-03; ATS Board of Directors 1997-04; ABIM Pulm Disease Brd 2004-06; APM Communications Committee 2004-06; Editorial Board, Respirology (2005-present).

HONORS/AWARDS:  Magna Cum Laude (1969); Alpha Omega Alpha (1972); Roche Award for Academic Achievement, U. of Pennsylvania School of Medicine (1973); American Lung Association Fellow (1978-19             80); VA Merit Review Program (1981-2008); NIH RO1:HL33247- (1985-9); NIH RO1:AI29103/HL65892 (1990-2005), Western Association of Physicians (1999-present), Association of American Physicians (elected 2002).

MAJOR PUBLICATIONS (selected from a total of 172)

133.   Payne TH, Fraser SA, Martin TR.  Computerized order entry in the ICU.  Clin Pulm Med 2001;8:284-289.

134.   Lucas R, Lijnen HR, Suffredini AF, Pepper MS, Steinberg KP, Martin TR, Pugin J.  Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin.  Thromb Haemost 2002;87:966-971.

135.   Frevert CW, Goodman RB, Kinsella MG, Kajikawa O, Ballman K, Clark-Lewis I, Proudfoot AEI, Wells TNC, Martin TR.  Tissue-specific mechanisms control the retention of IL-8 in lungs and skin.  J Immunol 2002;168:3550-3556.

140.  Bregeon F, Roch A, Delpierre S, Ghigo E, Autillo-Touati A, Kajikawa O, Martin TR, Pugin J, Portugal H, Auffray JP, Jammes Y.  Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription.  Resp Phys & Neurobiology 2002;132:191-203.

141.   Martin TR.  Neutrophils and lung inflammation: getting it right.  J Clin Invest 2002; 110:1603-1605.

142.   Rosengart MR, Nathens AB, Arbabi S, Neff MJ, Garcia I, Martin TR, Maier RV.  Mitogen-activated protein kinases in the intensive care unit: prognostic potential.  Annals of Surgery 2002;237:94-100.

143.   Martin TR, Nakamura M, Matute-Bello G.  The role of apoptosis in acute lung injury.  Crit Care Medicine 2003;31:S184-S188.

144.   Lee JS, Frevert CW, Thorning DR, Segerer S, Alpers CE, Cartron JP, Colin Y, Martin TR, Goodman RB.  Enhanced Expression of Duffy Antigen In the Lungs During Suppurative Pneumonia.  J Histochem Cytochem 2003 51:159-166.

145.   Frevert CW, Kinsella, MG Vathanaprida C Goodman RB, Baskin DG, Proudfoot A, Wells T, Wight TN, Martin TR.  Binding of IL-8 to Heparan Sulfate and Chondroitin Sulfate in Lung Tissue.  Am J Respir Cell Mol Biol 2003;28:464-472.

146.   Lee JS, Frevert CW, Wurfel MM, Peiper SC, Wong VA, Ballman KK, Ruzinski JT, Rhim JS, Martin TR, Goodman RB.  Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo.  J of Immunol 2003;170:5244-5251.

147.   Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS.  Injurious mechanical ventilation and end organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome.  JAMA 2003;289:2104-2112.

148.   Rai S, Engelberts D, Laffey JG, Frevert C, Kajikawa O, Martin TR, Post M, Kavanagh BP.  Therapeutic hypercapnia is not protective in in vivo surfactant depletion.  Pediatr Research 2003;55:1-8.

149.   Matute-Bello G, Martin TR.  Science review: Apoptosis in acute lung injury.  Crit Care 2003;7:355-358.

150.   Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T,Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S.  Elevation of KL-6, a lung epithelial cell marker in plasma and epithelial lining fluid in the acute respiratory distress syndrome.  Am J Physiol Lung Cell Mol Physiol 2004;286:L1088-L1094.

151.   Moriyama K, Ishizaka A, Nakamura M, Kubo H, Kotani T, Yamamoto S, Ogawa EN,  Kajikawa O, Frevert CW, Kotake Y, Morisaki H, Koh H, Taska S, Martin TR, Takeda J.  Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits.  Am J Physiol Lung Cell Mol Physiol 2004;286:L1114-L1121.

152.   Matute-Bello G, Martin TR.  Is Apoptosis Important in the Pathogenesis and Resolution of the Acute Respiratory Distress Syndrome?  In: Acute Respiratory Distress Syndrome, ed.  Matthay MA.  Marcel Dekker, New York, NY 2003, pp 181-200.

153.   Frevert CW, Martin TR.  Sepsis and the lung host response.  In: Pulmonary Host Defenses, Seminars in Respiratory and Critical Care Medicine 2004;25:85-93.

154.   Matute-Bello G, Winn RK, Martin TR, Liles WC.  Sustained LPS-induced lung inflammation in mice is attenuated by functional deficiency of the Fas/Fas ligand system.  Clin Diag Lab Immunol 2004;11:358-361.

155.   Lin SM, Frevert CW, Kajikawa O, Wurfel MM, Ballman K, Mongovin S, Wong VA, Selk A, Martin TR.  Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages. Am J Respir Cell Mol Biol 2004;31:162-170.

156.   Nakamura M, Matute-Bello G, Liles WC, Hayashi S, Kajikawa O, Lin SM, Frevert CW, Martin TR.  Differential response of human lung epithelial cells to Fas-induced apoptosis.  Am J Pathol 2004;164:1949-58.

157.   Altemeier WA, Matute-Bello G, Frevert CW, Kawata Y, Kajikawa O, Martin TR, Glenny RW.  Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin.  Am J Physiol Lung Cell Mol Physiol 2004;287:L533-L542.

158.   Matute-Bello G, Lee JS, Frevert CW, Liles WC, Sutlief S, Ballman K, Wong V, Selk A, Martin TR.  Optimal timing to repopulation of resident alveolar macrophages with donor cells following total body irradiation and bone marrow transplantation in mice.   J Immunol Methods 2004;292:25-34.

159.   Matute-Bello G, Liles WC, Frevert CW, Dhanireddy S, Ballman K, Wong V, Green RR, Song HY, Witcher DR, Jakubowski JA, Martin TR.  Blockade of the Fas/FasL system improves pneumococcal clearance from the lung without preventing bacteremic dissemination to the spleen.  J Infec Dis 2005;191:596-606.

160.   Bregeon F, Delpierre S, Roch A, Kajikawa O, Martin TR, Autillo-Touati A, Jammes Y.  Persistence of diaphragmatic contraction influences the pulmonary inflammatory response to mechanical ventilation.  Respir Physiol Neurobiol 2004;142:185-195.

161.   Martin TR.  Direct lung injury by bacteria: clarifying the tools of the trade.  Crit Care Med 2004;32:2360-2361.

162.   Kajikawa O, Frevert CW, Lin SM, Goodman RB, Mongovin SM, Wong V, Ballman K, Daubeuf B, Elson G, Martin TR.  Gene expression of toll-like receptor-2, toll-like receptor-4 and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia.  Gene 2005;3:193-202.

164.   Martin TR.  Cytokines and lung injury: searching for useful biomarkers.  Crit Care Med 2005;33:230.

165.   Bregeon F, Delpierre S, Chetaille B, Kajikawa O, Martin TR, Autillo-Touati A, Jammes Y, Pugin J.  Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia.  Anesthesiology 2005;102:331-339.

166.   Levy MM, Baylor MS, Bernard GR, Fowler R, Franks TJ, Hayden FG, Helfand R, Lapinsky SE, Martin TR, Niederman MS, Rubenfeld GD, Slutsky AS, Stewart TE, Styrt BA, Thompson BT, Harabin AL.  Clinical issues and research in respiratory failure from severe acute respiratory syndrome.  Am J Respir Crit Care Med 2005;171:518-526.

167.   Wurfel MM, Park WY, Radella F, Ruzinski J, Sandstrom A, Strout J, Bumgarner RE, Martin TR.  Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity.  J of Immunol 2005 (in press). 

168.   Martin TR, Hagimoto N, Nakamura M, Matute-Bello G.  Apoptosis and epithelial injury in the lungs.  Proceedings of the American Thoracic Society 2005 (in press).

169.   Matute-Bello G, Lee JS, Liles WC, Frevert CW, Mongovin S, Wong V, Ballman K, Sutlief S, Martin TR.  Fas-mediated acute lung injury requires Fas expression on non-myeloid cells of the lung.  J Immunol 2005 (in press).

170.   Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC.  Modulation of LPS-induced gene transcription and promotion of lung injury by mechanical ventilation.  J Immunol 2005 (in press).

172.   Lee JS, Frevert CW, Matute-Bello G, Wurfel MM, Wong VA, Lin SM, Ruzinski J, Mongovin S, Goodman RB, Martin TR.  TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.  Am J Physiol Lung Cell Mol Physiol 2005 (in press).