National Heart, Lung, and Blood Institute program in
Acute Lung Injury
Specialized Centers of Clinically Oriented Research (ALI SCCOR)

POSITIONS AND HONORS

1995-1996          Research Fellow, Rockefeller University, New York, NY
1997-1998          Intern, Internal Medicine, University of Washington, Seattle, WA
1998-2000          Resident, Internal Medicine, University of Washington, Seattle, WA
1999-2000          Chief Medical Resident, Swedish Medical Center, Seattle, WA
2000-2002     Fellow, Pulmonary & Critical Care Medicine, University of Washington, Seattle, WA
2002-2003     Senior Research Fellow, Pulmonary & Critical Care Medicine, University of Washington
2003-2004     Acting Instructor, Pulmonary & Critical Care Medicine, University of Washington, Seattle

PEER-REVIEWED PUBLICATIONS

 1.   Hailman E, Lichenstein HS, Wurfel MM, Miller DS, Johnson DA, Kelley M, Busse LA, Zukowski MM, Wright SD.  Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.  J Exp Med 1994;179:269.

2.    Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM.  Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family.  J Biol Chem 1994;269:18149.

3.    Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD.  Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med 1994;180:1025.

4.    Wurfel MM, Wright SD.  Lipopolysaccharide (LPS) binding protein catalyzes binding of LPS to lipoproteins.  Prog Clin Biol Res 1995;392:287.

5.    Wurfel MM, Hailman E, Wright SD.  Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein.  J Exp Med 1995;181:1743.

6.    Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D, Lamping N, Schumann RR, Thieringer R, Fenton MJ, Wright SD, Golenbock D.  Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.  J Exp Med 1997;186:2051.

7.    Wurfel MM, Wright SD.  Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid.  J Immunol 1997;158:3925.

8.        Lee JS, Frevert CW, Wurfel MM, Peiper SC, Wong VA, Ballman KK, Ruzinski JT, Rhim JS, Martin TR, Goodman RB.  Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo.  J of Immunol 2003;170:5244-5251.

9.        Lin SM, Frevert CW, Kajikawa O, Wurfel MM, Ballman K, Mongovin S, Wong VA, Selk A, Martin TR.  Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages. Am J Respir Cell Mol Biol 2004;31:162-170.

10.    Wurfel MM, Park WY, Radella F, Ruzinski J, Sandstrom A, Strout J, Bumgarner RE, Martin TR.  Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity.   J. Immunol. 2005 (in press).

11.    Hallstrand TS, Moody MW, Wurfel MM, Schwartz LB, Henderson Jr. WR, Aitken ML.  Inflammatory basis of exercise-induced bronchoconstriction.  Am J Respir Crit Care Med 2005 Jun 9 (Epub ahead of print).

12.    Lee JS, Frevert CW, Matute-Bello G, Wurfel MM, Wong VA, Lin SM, Ruzinski J, Mongovin S, Goodman RB, Martin TR.  TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.  Am J Physiol Lung Cell Mol Physiol 2005 (in press).

13.    Hallstrand TS,  Fischer ME,  Wurfel MM, Afari N, Buchwald D, Goldberg J.  Genetic pleiotropy between asthma and obesity in a community-based sample of twins. (in revision).

Review Articles

 1.    Lynch III JP, Wurfel MM, Flaherty K, et al.  Usual Interstitial Pneumonia. Seminars in Resp and Crit Care Med 2001;22:357-386.

2.    Wurfel MM, Raghu G.  Genetics of Pulmonary Fibrosis.  Seminars in Resp and Crit Care Med 2002;23:177-188.

3.    Wurfel MM, Raghu G.  Treatment of Idiopathic Pulmonary Fibrosis: New Directions. 2002.  Pulmonary and Critical Care Update: Online. 2002;16, Lesson 13. http://www.chestnet.org/education/pccu/vol16/lesson13.html